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目的:对阿仑膦酸钠治疗绝经后骨质疏松症的临床效果进行观察。方法:选择十堰市郧阳区中医院2013年9月至2014年11月绝经后骨质疏松症患者86例作为研究对象。随机分为对照组和观察组,每组43例。观察组患者口服阿仑膦酸钠片,对照组口服钙尔奇,两组接受药物治疗的时间均为12个月。记录并观察两组患者在骨痛评分、治疗有效率、安全性指标、骨密质变化等。结果:两组患者接受治疗之后,骨痛等状况得到明显的缓解,骨痛评分下降,在Ward氏三角区等对骨密度的比较,观察组效果优于对照组,比较差异具有统计学意义(P<0.05)。两组患者在接受治疗的过程中未现出骨折现象。两组患者在服用药物之后肝肾功能变化、血常规等都维持在正常的范围之内。结论:通过口服阿仑膦酸钠治疗绝经后骨质疏松症的方式可以有效提高患者骨密度,改善患者生产质量,缓解骨痛,安全有效。
Objective: To observe the clinical effect of alendronate in the treatment of postmenopausal osteoporosis. Methods: 86 cases of postmenopausal osteoporosis were selected from Yunyang District Hospital of Traditional Chinese Medicine in Shiyan City from September 2013 to November 2014. Randomly divided into control group and observation group, 43 cases in each group. Patients in the observation group were treated with alendronate sodium tablets orally, while those in the control group were orally administered with calcium. Both groups received drugs for 12 months. Record and observe the two groups of patients in bone pain score, treatment efficiency, safety indicators, changes in bone and cataracts. Results: After treatment, the condition of bone pain and other symptoms were relieved and the score of bone pain decreased. Compared with the control group, the Ward’s triangle area had better effect on bone mineral density, the difference was statistically significant ( P <0.05). Two groups of patients in the process of treatment did not show fracture phenomenon. Two groups of patients after taking drugs in liver and kidney function changes, blood, etc. are maintained within the normal range. Conclusion: The treatment of postmenopausal osteoporosis by oral alendronate can effectively improve the bone mineral density, improve patient quality of production and relieve bone pain, which is safe and effective.