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研究谷胱甘肽S 转移酶 (GST)在化学性肝毒物质溴苯所致小鼠肝损伤中的变化规律。结果表明 ,溴苯 15 0mg kgBW腹腔注射后 2h肝组织出现多个小灶性坏死 ,同时血清GST活性明显增高 ,注射 8h后血清丙氨酰转氨酶 (ALT)也开始增高 ,上述指标皆在给药后 16h达高峰 ,2 4h血清GST首先恢复正常。血清GST与肝组织病理学改变、血清ALT活性变化间皆存在高度的正相关。血清GST灵敏度、特异度和准确度分别为 89%、75 %和 82 % ,而血清ALT为 39%、92 %和 6 4%。诊断肝损伤的受试者工作特征曲线 (ROC)也进一步表明 ,血清GST比ALT更灵敏、更特异。提示血清GST能较好用于化学性肝损伤的预防和治疗监测。
To study the changes of glutathione S-transferase (GST) in liver injury induced by bromoxbenzene in mice with chemical hepatotoxicity. The results showed that multiple small focal necrosis of liver tissue occurred at 2h after intraperitoneal injection of bromobenzene 150mg kgBW, meanwhile serum GST activity increased significantly. Serum alanine aminotransferase (ALT) also began to increase after 8h injection of bromobenzene 16h peak, 24 h serum GST first return to normal. Serum GST and liver histopathological changes, changes in serum ALT activity are highly positive correlation exists. Serum GST sensitivity, specificity, and accuracy were 89%, 75%, and 82%, respectively, while serum ALT was 39%, 92%, and 64%. The receiver operating characteristic curve (ROC) for diagnosing liver damage further suggests that serum GST is more sensitive and specific than ALT. The results suggest that serum GST can be better used in chemical liver injury prevention and treatment monitoring.