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目的 探讨葡萄球菌肺炎患者发病早期体内细胞因子变化情况.方法 选取解放军总医院第一医学中心急诊科2016年1月-2018年3月确诊的葡萄球菌肺炎患者19例为病例组和健康志愿者20例为对照组,使用高通量细胞因子试剂盒检测外周血11种细胞因子水平.结果葡萄球菌肺炎组与对照组性别组成、年龄组成、吸烟情况无差异(均P＞0.05).葡萄球菌肺炎组IL-6、IFN-γ、MCP-1、TNF-α、TGF-α水平明显高于对照组(P＜0.05),葡萄球菌肺炎组EGF水平低于对照组(P＜0.05),两组IL-4、IL-8、IL-10、VEGF、FGF-2无统计学差异(P＞0.05).结论 IL-6、IFN-γ、MCP-1、TNF-α、EGF、TGF-α等细胞因子在葡萄球菌肺炎患者存在差异表达,检测细胞因子水平可为早期诊断葡萄球菌、评估患者病情变化提供依据.“,”Objective To investigate the changes of the cytokine and in patients with staphylococcus pneumonia. Method 19 patients with staphylococcus pneumonia in the emergency department from Jun.2016 to Mar.2018 were chosen as the pneumonia group and 20 health adult were set as the control group.The levels of 11 cytokines were detected by using Human Cytokine/Chemokine Panel. Results There was no difference in sex, age and smoking between staphylococcal pneumonia group and control group (P＞0.05).The levels of IL-6、IFN-γ、MCP-1 and TNF-α、TGF-α of staphylococcal pneumonia group was higher than control group(P<0.05).The level of EGF was lower(P<0.05).There was no significant difference in the level of IL-4、IL-8、VEGF、FGF-2 and IL-10. Conclusion The levels of IL-6、IFN-γ、MCP-1、TNF-α、EGF、TGF-α were different.Detection of cytokine can help to assess changes in patients’condition and provide early warning of prognosis.