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目的 :研究冠心病充血性心力衰竭 (CHF)患者血清肿瘤坏死因子 (TNF)和外周血红细胞免疫功能变化。方法 :收集 31例冠心病CHF患者血液标本 ,以放射免疫液相竞争法检测血清TNF ,采用郭峰法测定红细胞免疫功能RC3bRR ,RICR。结果 :冠心病CHF患者血清TNF高于对照组 (P <0 .0 5 ) ,RC3bRR低于对照组 (P<0 .0 0 1) ,RICR高于对照组 (P <0 .0 1)。年龄、性别、心功能级别不同对各项指标无显著影响 (P >0 .0 5 )。直线相关分析 ,RC3bRR与RICR呈负相关 ,但无显著性 (r=- 0 .2 2 6 ,P >0 .0 5 ) ,RC3bRR和RICR均与TNF无显著相关 (P >0 .0 5 )。结论 :冠心病CHF患者存在免疫功能异常 ,TNF和红细胞免疫功能异常各自作为独立因素参与了冠心病CHF的发生发展过程。
Objective: To study the changes of serum tumor necrosis factor (TNF) and peripheral erythrocyte immune function in patients with coronary heart disease and congestive heart failure (CHF). Methods: Blood samples were collected from 31 CHF patients with coronary heart disease. The levels of serum TNF were measured by radioimmunoassay. The erythrocyte immune function RC3bRR and RICR were determined by GuoFeng method. Results: Serum TNF of patients with coronary heart disease was higher than that of the control group (P <0.05). RC3bRR was lower than that of the control group (P <0.01), and RICR was higher than that of the control group (P <0.01). Age, gender, and different levels of heart function had no significant effect on each index (P> 0.05). There was a negative correlation between RC3bRR and RICR (r = - 0.226, P> 0.05). There was no significant correlation between RC3bRR and RICR (P> 0.05) . CONCLUSIONS: CHF patients with coronary heart disease have abnormal immune function and TNF and erythrocyte immune dysfunction are independent factors involved in the development and progression of CHF in patients with coronary heart disease.