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目的：研究氯氨酮是否可以直接作用于外周伤害性感受器而产生镇痛．方法：一对不锈钢针插入尿酯麻醉的大鼠一侧后肢的两足脂皮下，施加强电流（２ｍｓ，８０Ｖ，２－３脉冲，０５Ｈｚ）作为伤害性刺激，在同一后肢的后二头半腱肌记录肌电反应，电刺激引起的长潜伏期Ｃ成分，作为伤害性屈反射的指标．结果：在邻近刺激电极的跖部皮下注射氯氨酮（３６ｍｍｏｌ·Ｌ－１，５μＬ）可明显抑制Ｃ反应，注射氯氨酮后９分钟，在同一部位注射５μＬ的１％纳络酮，可翻转抑制效应．结论：氯氨酮可直接作用外周伤害性感受器产生镇痛，并提示可能与外周阿片受体的激活有关．
OBJECTIVE: To investigate whether ketamine can exert analgesia directly on peripheral nociceptors. METHODS: A pair of stainless steel needles were implanted under the bilirubin of one hindlimb of ureter anesthetized rats, and applied strong current (2ms, 80V, 2-3 pulses, 05Hz) as nociceptive stimulus. The first semitendinosus muscle records myoelectric response, electrical stimulation caused by long incubation period C component, as an index of nociceptive reflex. RESULTS: C-reaction was significantly inhibited by injection of ketamine (36 mmol·L-1, 5 μL) subcutaneously to the plantar mass of the stimulation electrode. Nine minutes after the injection of ketamine, 5 μL of 1% naloxone was injected at the same site Flip suppression effect. CONCLUSION: Ketamine can directly induce the peripheral nociceptors to produce analgesia, and may be related to the activation of peripheral opioid receptors.