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目的 :观察高频呼吸机治疗足月儿MAS的临床效果。方法 :以2012年3月~2015年6月在我院接受治疗的胎粪吸入综合征患儿为观察对象,根据其治疗方式分为常频机械通气组和高频机械通气组,每组各40例患儿。观察两组患儿机械通气时间,比较两组患儿治疗前后血氧指标的变化,并对两组患儿的疾病转归进行观察。结果 :高频机械通气组患儿的总机械通气时间、撤机后给氧时间均短于常频机械通气组,差异有统计学意义;两组患儿通气前的吸入氧分数、氧分压、二氧化碳分压和血酸碱度无明显差别,通气4小时和12小时后,高频机械通气组吸入氧分数、二氧化碳分压低于常频机械通气组,氧分压和血酸碱度高于常频机械通气组,差异具有统计学意义;两组患儿死亡、颅内出血、肺出血和呼吸机相关性肺炎发生率无明显差别,而高频机械通气组视网膜病变的发生率明显低于常频机械通气组。结论 :高频呼吸机对足月儿MAS有较好的治疗效果,且并发症发生率低,具有临床应用价值。
Objective: To observe the clinical effect of high-frequency ventilator in treating full-term children with MAS. Methods: The children with meconium aspiration syndrome who were treated in our hospital from March 2012 to June 2015 were divided into two groups according to their treatment: the normal-frequency mechanical ventilation group and the high-frequency mechanical ventilation group 40 cases of children. The duration of mechanical ventilation in both groups was observed. The changes of blood oxygen index before and after treatment were compared between the two groups, and the disease outcome was observed in both groups. Results: The total mechanical ventilation time and the oxygenation time after weaning in children with high-frequency mechanical ventilation were shorter than those in the normal-frequency mechanical ventilation group, the difference was statistically significant; before inhalation, the oxygen intake, oxygen partial pressure , Partial pressure of carbon dioxide and blood pH no significant difference between 4 hours and 12 hours after ventilation, high-frequency mechanical ventilation group inhaled oxygen fraction, partial pressure of carbon dioxide than normal frequency mechanical ventilation group, partial pressure of oxygen and blood pH is higher than the frequency of mechanical ventilation Group, the difference was statistically significant; two groups of children with death, intracranial hemorrhage, pulmonary hemorrhage and ventilator-associated pneumonia no significant difference in the incidence, while the incidence of retinopathy of high-frequency mechanical ventilation group was significantly lower than the frequency of mechanical ventilation group . Conclusion: High-frequency ventilator has good therapeutic effect on full-term children with MAS, and the incidence of complications is low, which has clinical value.