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目的分析了食管癌相关基因4在食管癌组织中的表达水平和修饰与食管癌预后的关系。方法收集食管癌手术后的食管癌肿瘤组织91例作为研究标本。采用免疫组化对肿瘤组织中的蛋白质表达水平进行分析。并分析ECRG4的表达水平与患者生存的关系。结果免疫组织化学鉴定ECRG低表达74例,高表达17例。ECRG4高表达患者术后5年累积复发率明显低于ECRG4低表达患者5年累积复发率(P<0.05)。而ECRG4高表达患者术后5年累积生存率明显高于ECRG4低表达患者5年累积生存率(P<0.05)。结论 ECRG4在食管癌肿瘤组织中呈低表达或不表达,与术后复发和生存有密切相关。
Objective To analyze the relationship between the expression of esophageal carcinoma-related gene 4 in esophageal cancer tissues and the prognosis of esophageal cancer. Methods 91 cases of esophageal cancer tissue after esophageal cancer surgery were collected as research samples. Immunohistochemistry was used to analyze the protein expression levels in tumor tissues. And analyze the relationship between the expression level of ECRG4 and the survival of patients. Results Immunohistochemistry identified 74 cases of low ECRG expression and 17 cases of high expression. The 5-year cumulative recurrence rate of patients with high ECRG4 expression was significantly lower than that of patients with low ECRG4 expression (P <0.05). The 5-year cumulative survival rate of patients with high ECRG4 expression was significantly higher than that of patients with low ECRG4 expression (P <0.05). Conclusion ECRG4 is low or not expressed in esophageal cancer tissues, which is closely related to recurrence and survival.