全球大约有10%~15%的夫妇不育,约50%是男性因素导致的,其中遗传因素是重要且原因明确的因素。遗传因素主要包括染色体病和Y染色体的微缺失,其中染色体病,包括染色体平衡易位、罗伯逊易位、倒位以及性染色体异常等。Y染色体长臂远端区域存在控制精子发生的基因为无精子症因子(azoospermic factor,AZF),这一区域的染色体微 About 10% to 15% of the world’s couples are infertile, about 50% are caused by men, of which genetic factors are important and the reason is clear. Genetic factors include chromosome disease and Y chromosome microdeletions, including chromosome disease, including chromosome balance translocation, Robertson translocation, inverted and sex chromosome abnormalities. Y chromosome long arm distal region exist spermatogenesis control gene for azoospermic factor (azoospermic factor, AZF), the region of chromosome micro