息斯敏(hismnal astemizoli)是长效及强效的H1受体拮抗剂,临床常用于过敏性疾患的治疗。其服用过量可引起严重的心律失常。我科收治一例息斯敏重度中毒患者,抢救成功,现报道如下。 患者,女,23岁,未婚。一次口服息斯敏500mg(50片),4小时后恶心、呕吐,当时未就诊,10小时后感上述症状加重并有烦躁,眼前发黑,急送我科。既往体健,无心血管疾病及遗传病史。查体:T:36℃,P:120次/分,R:22次/分,BP:15/10kPa,神清,急性痛苦病容,肺无罗音,心率120次/分,律齐,无杂音,肝脾未及,未引出病理征。立即予以洗胃、补液、利尿后留 Hismnal astemizoli is a long-acting and potent H1-receptor antagonist commonly used clinically in the treatment of allergic conditions. Overdose can cause severe arrhythmia. Our department admitted a case of aspartame severe poisoning, rescue success, are reported below. Patient, female, 23 years old, unmarried. An oral astemizole 500mg (50 tablets), 4 hours after nausea and vomiting, was not treated, 10 hours later the above symptoms aggravated and irritability, black eyes, urgent delivery to our department. Past physical health, no cardiovascular disease and genetic history. Check the body: T: 36 ℃, P: 120 beats / min, R: 22 beats / min, BP: 15 / 10kPa, Shen Qing, acute pain and disease, lung rales, heart rate 120 beats / Noise, no liver and spleen, did not lead to pathological sign. Immediate gastric lavage, fluid, diuretic stay