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目的探讨拉米夫定联合干扰素治疗慢性乙型肝炎的临床效果。方法选取收治的慢性乙型肝炎患者90例,随机分为对照组和观察组,对照组单用拉米夫定治疗,观察组在对照组的基础上加用干扰素治疗。比较两组治疗效果及副反应发生情况。结果对照组总有效率66.2%,观察组总有效率77.8%,两组总有效率差异有统计学意义(P<0.05)。两组治疗过程中均未见明显不良反应发生。结论拉米夫定联合干扰素治疗慢性乙型肝炎,总有效率高,副作用少,值得临床推广应用。
Objective To investigate the clinical efficacy of lamivudine combined with interferon in the treatment of chronic hepatitis B. Methods Ninety patients with chronic hepatitis B who were admitted to our hospital were randomly divided into control group and observation group. The control group was treated with lamivudine alone. The observation group was treated with interferon on the basis of the control group. Compare the two groups of treatment effects and side effects. Results The total effective rate was 66.2% in the control group and 77.8% in the observation group. There was significant difference between the two groups in total effective rate (P <0.05). No significant adverse reactions occurred in both groups during the course of treatment. Conclusion Lamivudine combined with interferon in the treatment of chronic hepatitis B, the total effective rate, fewer side effects, worthy of clinical application.