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菲啶骨架化合物是一类重要的有机分子并广泛存在于天然产物中,也是一类重要的抗菌抗癌的生物活性分子.通过钯催化二炔和芳卤经[2+2+2]环化加成反应,发展了一种高效实用的制备二氢菲啶衍生物的Domino方法.所合成目标产物的结构经IR、1H NMR、13C NMR和HRMS表征确证,其中7,12-二苯基-5-对甲苯磺酰基-5,6-二氢苯并[j]菲啶-10-乙酮(3b)的结构还通过X射线单晶衍射分析确认.
Phenanthridine skeleton compounds are an important class of organic molecules and are widely distributed in natural products and are also a kind of important antimicrobial and anticancer bioactive molecules. Palladium-catalyzed cyclization of diyne and aryl halides by [2 + 2 + 2] Addition reaction, the development of a highly efficient and practical method for the preparation of dihydrophenanthridine derivative Domino structure of the target product by IR, 1H NMR, 13C NMR and HRMS characterization confirmed 7,12-diphenyl- The structure of 5-p-toluenesulfonyl-5,6-dihydrobenzo [j] phenanthridin-10-ethanone (3b) was also confirmed by X-ray single crystal diffraction analysis.