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设计并合成４种金属酞菁（六羧基酞菁钴、四羧在酞菁钴、六磺酸基酞菁钴、四磺酸基酞菁钴）作为ＳＯＤ和ＣＡＴ双功能模拟酶。对其仿ＳＯＤ和ＣＡＴ的部分生物学功能进行检测。结果显示：核黄素－蛋氨酸光明法证实它们在１０－５～１０－６ｍｏｌ／Ｌ浓度范围内有清除Ｏ２－的作用；分光光度法证实它们能催化Ｈ２Ｏ２的分解，且分解率随浓度增大而增大；用小鼠肝匀浆法测定４种金属酞菁、ＳＯＤ和ＣＡＴ，均表明有良好抗脂质过氧化作用；用多形核白细胞（ＰＭＮ）－鲁米诺化学发光测定呼吸爆发中的活性氧，表明模拟酶对活性氧有清除作用；大鼠心脏缺血再灌注实验表明六羧基酞菁钴能降低活性氧对心肌的损伤程度，对再灌注损伤心肌有保护作用。
Four kinds of metal phthalocyanines (hexacarboxyphthalocyanine cobalt, tetracarboxylates cobalt phthalocyanine, cobalt hexacosuccinate, cobalt tetrasulfonate phthalocyanine) were designed and synthesized as SOD and CAT bifunctional mimic enzymes. Some of its imitation of SOD and CAT biological function tests. The results showed that riboflavin-methionine light method confirmed that they could scavenge O2- in the concentration range of 10-5 ~ 10-6mol / L; spectrophotometry confirmed that they could catalyze the decomposition of H2O2, and the decomposition rate increased with increasing concentration And increased with the method of mouse liver homogenate assay of four kinds of metal phthalocyanine, SOD and CAT, both showed good anti-lipid peroxidation; polymorphonuclear leukocytes (PMN) - luminol chemiluminescence determination of respiratory burst In the reactive oxygen species, indicating that mimic enzymes scavenging reactive oxygen species; rat heart ischemia-reperfusion experiments show that carboxymethyl cobaltcarboxylate can reduce reactive oxygen species damage to the myocardium, myocardial ischemia reperfusion injury.