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目的分析绝经前不同年龄段乳腺癌的临床特征,并比较其预后的差异。方法回顾性收集四川省肿瘤医院1999年1月至2011年9月收治的729例绝经前乳腺癌患者的临床资料及随访资料。按年龄分为35岁以下组131例、36~45岁组402和46岁以上组196例。结果在初潮年龄、活产次数和体重指数方面3组差异有统计学意义,临床特征、5年无病生存率(DFS)和5年总生存率(OS)3组的差异均无统计学意义,按分子亚型进行分层分析,绝经前三阴型乳腺癌的5年无病生存率分别为85.7%、88.7%和76.2%(P<0.05)。临床分期为早期,淋巴结≤3个、肿瘤大小≤2 cm和luminal A型是OS的预后因素。结论年龄没有作为绝经前乳腺癌预后因素的价值,高龄的三阴型绝经前乳腺癌预后差。
Objective To analyze the clinical features of different stages of premenopausal women with breast cancer and to compare their prognostic differences. Methods The clinical data and follow-up data of 729 cases of premenopausal breast cancer admitted to Sichuan Cancer Hospital from January 1999 to September 2011 were retrospectively collected. According to age, 131 cases were below 35 years old, 402 cases were from 36 to 45 years old and 196 cases were over 46 years old. Results There were significant differences among the three groups in terms of menarche age, live birth number and body mass index. There was no significant difference in clinical features, 5-year disease-free survival (DFS) and 5-year overall survival (OS) The 5-year disease-free survival rates of premenopausal women with triple-negative breast cancer were 85.7%, 88.7% and 76.2%, respectively (P <0.05). The clinical stage was early, lymph node ≤ 3, tumor size ≤ 2 cm and luminal A type were prognostic factors of OS. Conclusion Age is not as a prognostic factor for premenopausal breast cancer, and advanced triadic premenopausal women have a poor prognosis.