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通过对１７６个女性肺癌先证者核心家系和１９４个女性对照的核心家系资料分析。发现女性肺癌先证者的一级亲属（父母、同胞）患肺癌的危险性是对照一级亲属（父母、同胞）的１．６７倍，且差异具有显著性。其中女性亲属患肺癌的危险性显著高于对照的女性亲属，ＯＲ值为２．８１（Ｐ＜０．０１）。女性肺癌的遗传度为２０．５４％，遗传因素是女性肺癌的重要危险因素。女性肺癌先证者的女性亲属对肺癌的遗传易感性比男性亲属高。这些结果有助于全面阐明云南省宣威县女性肺癌高发的原因。
Analysis of core family data from 176 female lung cancer proband core families and 194 female controls. The risk of lung cancer among first-degree relatives (parents, siblings) of female lung cancer probands was found to be 1.67 times that of the control first-degree relatives (parents and siblings), and the difference was significant. Among the female relatives, the risk of lung cancer was significantly higher than that of the control relatives, with an OR of 2.81 (P<0.01). The heritability of female lung cancer is 20.54%. Genetic factors are important risk factors for female lung cancer. Female relatives of female lung cancer probands have higher genetic susceptibility to lung cancer than male relatives. These results help to fully clarify the causes of the high incidence of lung cancer in women in Xuanwei County, Yunnan Province.