长期以来,在布病的临床工作中最棘手的问题就是缺乏临床诊断的客观指标,因而增加了布病的临床诊断和疗效判定的难度,作者从1985年以来,陆续进行了一些有关项目的观察。1 观察对象和方法1.1 对象 对凡有布病流行病学接触史,有布病的临床症状和体征,皮试阳性和血清学检查一项阳性者,作为观察对象,并以健康人群作为对照。1.2 方法 For a long time, the most intractable problem in the clinical work of brucellosis is the lack of objective indicators of clinical diagnosis, thus increasing the difficulty of clinical diagnosis and curative effect determination of brucellosis. Since 1985, the author has carried out some observations on related projects . 1 observed objects and methods 1.1 subjects where there is a history of epidemiology brucellosis, clinical symptoms and signs of brucellosis, skin test positive and serological tests were positive, as the observation object, and the healthy population as a control. 1.2 method