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目的:建立乳酸亚铁胶囊溶出度的检查方法和测定方法。方法:以0.1mol·L~(-1)盐酸溶液为溶出介质,蓝法,转速为50r·min~(-1),取样时间30min,以原子吸收分光光度法在248.35nm波长处进行测定。结果:亚铁离子检测浓度的线性范围为0.5~5.0μg·m L~(-1)(r=0.999);平均回收率为99.63%,RSD=0.2%。结论:所用方法准确、可靠,可用于测定该制剂的溶出度。
Objective: To establish a method and method for the determination of dissolution of ferrous lactate capsules. Method: 0.1mol·L ~ (-1) hydrochloric acid solution was used as the dissolution medium. The speed of the method was 50r · min ~ (-1) and the sampling time was 30min. The determination was made at the wavelength of 248.35nm by atomic absorption spectrophotometry. Results: The linear range of ferrous ion concentration was 0.5-5.0 μg · m L -1 (r = 0.999). The average recovery was 99.63% and RSD was 0.2%. Conclusion: The method used is accurate and reliable and can be used to determine the dissolution rate of the preparation.