20%～50%的胰岛素依赖型糖尿病(IDDM)患儿有明显的骨质丢失,具有骨折的高度危险性。这与血清电解质代谢的变化及PTH-Vit D 内分泌系统的紊乱有关。血清镁浓度降低可影响甲状旁腺功能及α-l羟化酶的活性。对一组低镁血症的 IDDM 患儿补镁60天,观察其对PTH-Vit D 内分泌系统的作用。对象 23例用胰岛素及饮食疗法的患儿,无糖尿病并发症及任何可干扰 Ca~(++)及/或骨代谢的其他疾 20% to 50% of children with insulin-dependent diabetes mellitus (IDDM) have significant loss of bone mass and a high risk of fractures. This is associated with changes in serum electrolyte metabolism and disorders of the PTH-Vit D endocrine system. Decreased serum magnesium can affect parathyroid function and α-l hydroxylase activity. A group of IDDM children with hypomagnesemia magnesium for 60 days to observe the role of PTH-Vit D endocrine system. Subjects 23 children with insulin and diet therapy, no complications of diabetes and any other diseases that can interfere with Ca ~ (++) and / or bone metabolism