Peripheral nerves coordinate signal transduction from the periphery to the central nervous system for processing and transmission back as required for normal mammalian function. Peripheral nerves and nerve roots are structurally divided into three compartments: the outermost epineurium, inner perineurium that surrounds nerve fascicles and the innermost endoneurium (Mizisin and Weerasuriya, 2011). As with all organs, peripheral nerve vascularization occurs during development and is maintained in health. Adaptations are expected dependent on tissue-specific functions and physiologic state.