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目的探讨测定血降钙素原(PCT)和C反应蛋白(CRP)水平在重症感染患者中临床意义.方法选择符合诊断标准的46例重症感染患者,其中治疗4d后好转患者28例,恶化患者18例;30例一般感染组,测定各组患者入院及经治疗4d的血清PCT和CRP水平.结果入院时PCT值及CRP值,重症感染好转组、恶化组与一般感染组相比均有显著性差异(P0.05),而PCT有显著性差异(P0.05).结论血清PCT值及CRP值的高低与感染严重程度有关,PCT及CRP越高,病情越重,重症感染可能性越大,特别是PCT,更能反应病人预后情况,两者均能及时反应治疗效果,为临床评估重症感染病情发展及疗效提供参考.“,”Objective To explore the clinical significance of determining serum PCT and CRP in patients with severe infection.Method 46 cases of severe infection met the criterion,including 28 patients,better after treatment for 4 days,18 patients deteriorated;30 cases of general infection hospital admission,serum PCT and CRP levels were measured 4 days after treatment in each groups.Results PCT values and CRP on admission,in severe infection,improved group,deterioration group has significant difference(P0.05) in severe deterioration improving group while PCT were significantly different(P0.05).Conclusion The values of serum PCT and CRP are correlated with the severity of infection.The higher PCT and CRP in the more severe disease,the greater the likelihood of severe infection,especially PCT could better reflect the prognosis of patients.Both can supply for the clinical assessment of progression and effect of treatment response for severe infection.