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本文在体外对EGb761能否抑制钢离子诱导的人血清低密度脂蛋白氧化修饰进行了研究。低密度脂蛋白（LDL）用EGb76140，80，160mg·L(-1)‘预处理1h，然后用CuSO410μmol·(-1)氧化修饰10h。结果表明LDL被钢离子氧化修饰后低密度脂蛋白中维生素E（VE）被耗竭，丙二醛（MDA）及自身荧光物质（LF）含量升高，载脂蛋白B（apoB）的电泳迁移速率加快。EGb761剂量依赖性地抑制VE的含量降低和MDA及自身荧光物质的含量升高，载脂蛋白B的电泳迁移速率依次减慢。可见在体EGb761能抑制钢离子诱导的人血清低密度脂蛋白氧化修饰。
In this paper, whether EGb761 can inhibit steel ion-induced human serum LDL oxidation modification was studied in vitro. Low-density lipoprotein (LDL) was pretreated with EGb76140, 80, 160 mg·L(-1) for 1 h, and then oxidatively modified with CuSO410 μmol·(-1) for 10 h. The results showed that the vitamin E (VE) was depleted, the content of malondialdehyde (MDA) and autofluorescence (LF) increased, and the electrophoretic migration rate of apoB in LDL was modified by oxidation of LDL. accelerate. EGb761 dose-dependently inhibited the decrease of VE content and the content of MDA and autofluorescent substances. The electrophoretic migration rate of apolipoprotein B decreased in turn. It can be seen that in vivo EGb761 can inhibit the oxidation of human serum low density lipoprotein induced by steel ions.