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目的观察安宫牛黄注射液对脑外伤后脑内炎性反应因子白细胞介素(IL)-1β、细胞间黏附分子(ICAM)-1、血清S100B蛋白和神经元特异性烯醇化酶(NSE)水平的影响,探讨其对外伤脑组织的保护作用。方法采用Feeney法造成鼠脑挫裂伤模型,在伤后不同时相点用酶联免疫法检测治疗组和对照组脑组织IL-1β、ICAM-1水平、血清S100B蛋白和NSE水平变化。结果除外IL-6β伤后6 h外,伤后6～48 h治疗组脑组织IL-1β、ICAM-1、血清S100B蛋白和NSE均比对照组低(P＜0．05)。结论安宫牛黄注射液能减轻脑外伤后脑组织的炎症反应,对脑组织起一定的保护作用。
Objective To observe the levels of inflammatory cytokines interleukin (IL)-1β, intercellular adhesion molecule (ICAM)-1, serum S100B protein and neuron-specific enolase (NSE) in brain after brain injury induced by Angong Niuhuang injection The impact of the study on its protective effect on traumatic brain tissue. Methods The Feeney method was used to establish the rat brain contusion model. The levels of IL-1β, ICAM-1, and serum S100B protein and NSE levels in the brain of the treatment and control groups were detected by enzyme-linked immunosorbent assay at different time points after injury. Results Compared with the control group, the levels of IL-1β, ICAM-1, serum S100B protein and NSE in the brain tissue of the treatment group were lower than those of the control group at 6 to 6 hours after IL-6β injury (P<0.05). Conclusion Angong Niuhuang injection can reduce the brain tissue inflammatory reaction after brain injury, and it can protect the brain tissue.