目的探讨本地区由支原体引起的女性生殖道感染的药物敏感性变化,寻求防止支原体耐药菌株产生的有效办法.方法将237例生殖道支原体感染患者分为 A、B 组.A 组118例为未做药敏试验,经用药临床症状未见好转而来我院就诊,B 组为119例我院初诊患者.两组患者均做支原体培养鉴定并做药敏试验,根据药敏试验结果用药治疗1个疗程(14天),随访观察治疗效果.结果 AB 两组对四环素耐药率差异无统计学意义;AB 两组对环丙沙星呈高度耐药;A 组对大环内酯类药物耐药率显著高于 B 组.A 组显效率72.9%,B 组显效率94.1%,两组差异有统计学意义(P﹤0.005).结论不规范用药可导致支原体耐药率上升,支原体培养和药敏试验对指导临床选择药物合理治疗,降低耐药菌株产生,缩短疗程有重要意义,“,”Objective To explore the drug sensitivity of female genital tract infections caused by mycoplasma,find effective ways to prevent the emergence of mycoplasma resistant strains.Methods 237 genital tract mycoplasma infection cases were divided into group A,B.118 patients of group A without drug sensitive test,clinical symptoms did not improve after treatment,then turn to our hospital.119 cases of group B patients were first visit to our hospital. Mycoplasma culture identification and drug sensitive test were actualized in two groups.According to the results of drug sensitivity test,treatment for 1 courses(14 days),folow-up observation of treatment. Results The resistant to tetracycline was no significant difference between the two groups.Two groups were highly resistant to ciprofloxacin.The macrolide resistance rates in group A were significantly higher than that of B group. The significant efficiency rate in group A was 72.9%,group B was 94.1%,there was significant difference between two groups (P﹤0.005). Conclusion Drugs abuse can lead to rising drug resistance rates of mycoplasma.Mycoplasma culture and drug sensitivity had important significance for clinical drugs choice,reasonable treatment,reduced resistant strains,shorten treatment course.