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系统性红斑狼疮( systemic lupus erythematosus,SLE)为自身免疫性疾病,SLE患者的心血管疾病发生率及死亡率均高于普通人群,尤其是动脉粥样硬化( atherosclerosis AS)性疾病。但传统的危险因素不能完全解释其机制,新发现的危险如高同型半胱氨酸血症、胰岛素抵抗、代谢综合征和自身抗体也可能起重要作用。 SLE与AS的发生发展有密切关系,现就SLE易伴发 AS的可能机制做一综述。“,”Systemic lupus erythematosus ( SLE) are autoimmune disorders. The incidence and morbidity of coronary artery disease are much higher in SLE than in the general popula-tion. But traditional cardiovascular risk factors do not ful y explain the excessive cardiovascular events, some new factors, such as high cysteine, insulin resistance,metabolic syndrome and in-flammation may play an important role . There is a close relationship between SLE and AS development. This review provides the possible mechanism in the SLE easily with atherosclerosis.