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目的:探讨骨髓增生异常综合征合并非霍奇金淋巴瘤的发病机制、诊断及治疗,并判断其预后情况。方法:回顾我院收治的一例骨髓增生异常综合征(MDS)患者同时诊断间变大细胞淋巴瘤(ALCL)患者的临床资料,总结其诊断及治疗经过,对其预后进行评价。结果:该患者诊断间变大细胞淋巴瘤后,经化疗对症治疗病情无显著改善,且患者ALK阳性,考虑预后较差,建议造血干细胞移植。结论:骨髓增生异常综合征合并非霍奇金淋巴瘤的病例在国内外十分罕见,治疗方法目前尚需进一步研究。
Objective: To investigate the pathogenesis, diagnosis and treatment of myelodysplastic syndromes complicated with non-Hodgkin’s lymphoma and to determine the prognosis. Methods: The clinical data of one patient with myelodysplastic syndrome (MDS) diagnosed at the same time in diagnosis of patients with metastatic large cell lymphoma (ALCL) were retrospectively reviewed. The diagnosis and treatment were summarized and the prognosis was evaluated. Results: After diagnosing anaplastic large cell lymphoma, the patient had no significant improvement in symptomatic treatment by chemotherapy, and positive ALK in patients. Considering the poor prognosis, hematopoietic stem cell transplantation was suggested. Conclusion: The cases of myelodysplastic syndromes complicated with non-Hodgkin’s lymphoma are rare at home and abroad. The treatment methods need further study at present.