本文用冷干法和共沉法制备了消炎痛和β-环糊精复合物。实验证明两种复合物的溶出速率明显增加,但对大鼠的局部刺激性却未见减轻。应用荧光分光光度法测定了产品所含消炎痛的血药浓度,结果表明冷干品的生物利用度有所提高,但统计上无显著性差异。 Indomethacin and β-cyclodextrin complex were prepared by cold-dry method and co-precipitation method. Experiments show that the dissolution rate of the two complexes increased significantly, but the local irritation in rats but no reduction. Fluorescence spectrophotometry was used to determine the plasma concentration of indomethacin in the product. The results showed that the bioavailability of the cold-dried product increased, but there was no statistically significant difference.