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目的:观察多巴胺和多巴酚丁胺联合治疗新生儿窒息后肾损害的临床应用价值。方法:收集2011年1月～2012年7月期间新乡市妇幼保健院新生儿重症监护病房的新生儿窒息患儿240例,其中肾损害130例,将患儿随机分为对照组(n=60)和多巴胺联合多巴酚丁胺治疗组(n=70)。检测患儿治疗前后血尿素氮和肌酐的表达变化,统计分析两组治疗效果。结果:该院新生儿窒息肾损害的发生率为54.5%。对照组和治疗组在治疗前血尿素氮和肌酐的表达水平无统计学差异(P>0.05),治疗后治疗组对血尿素氮和肌酐的减低效果显著优于对照组(P<0.05)。治疗组的临床治疗有效率为94.3%显著高于对照组的73.3%(P<0.05)。结论:多巴胺联合多巴酚丁胺辅助治疗新生儿窒息后肾损害临床疗效显著,值得临床推广应用。
Objective: To observe the clinical value of combination of dopamine and dobutamine in the treatment of nephropathy after neonatal asphyxia. Methods: A total of 240 neonates with neonatal asphyxia in Xinxiang Maternal and Child Health Hospital from January 2011 to July 2012 were enrolled. Among them, 130 cases of renal damage were included in the study. The children were randomly divided into control group (n = 60) ) And dopamine plus dobutamine (n = 70). Changes in blood urea nitrogen and creatinine in children before and after treatment were measured, and the treatment effects were statistically analyzed. Results: The incidence of neonatal asphyxia and kidney damage in this hospital was 54.5%. There was no significant difference in blood urea nitrogen and creatinine level between the control group and the treatment group before treatment (P> 0.05). After treatment, the blood urea nitrogen and creatinine reduction effect of the treatment group was significantly better than that of the control group (P <0.05). The effective rate of clinical treatment in the treatment group was 94.3%, significantly higher than that in the control group (73.3%, P <0.05). Conclusion: The combination of dopamine and dobutamine in the treatment of nephropathy after neonatal asphyxia is clinically effective and worthy of clinical application.