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目的:通过检测高血压急症患者血管内皮功能及动脉弹性,探讨高血压急症发生的可能机制。方法:在该院急诊科就诊的高血压患者120例,其中高血压急症患者79例,稳定性高血压患者41例。采用高分辨率血管超声法检测患者肱动脉血流介导的血管舒张功能(FMD);应用动脉弹性功能检测仪测定受试者的大动脉弹性指数(C1)和小动脉弹性指数(C2)。结果:高血压急症组FMD明显低于稳定性高血压组[(6.90±4.14)%对比(8.66±4.17)%,P<0.05];高血压急症组与稳定性高血压组的C1比较差异无统计学意义[(11.27±3.77)ml/mmHg(1mmHg=0.133kPa)×10对比(11.57±3.88)ml/mmHg×10,P(0.05],但高血压急症组的C2明显低于稳定性高血压组[(4.48±2.14)ml/mmHg×100对比(5.41±2.35)ml/mmHg×100,P<0.05]。结论:与稳定性高血压患者相比,高血压急症患者FMD降低和小动脉弹性指数损伤更严重。
Objective: To explore the possible mechanism of hypertensive emergencies by detecting vascular endothelial function and arterial elasticity in hypertensive patients. Methods: A total of 120 hypertensive patients were enrolled in the emergency department of the hospital, including 79 cases of hypertensive emergency and 41 cases of stable hypertension. The brachial artery blood flow-mediated vasodilation (FMD) was measured by high-resolution blood vessel sonography. The arterial elasticity index (C1) and arteriolar elasticity index (C2) were measured by arterial elasticity test. Results: The FMD of acute hypertension group was significantly lower than that of stable hypertension group [(6.90 ± 4.14)% vs (8.66 ± 4.17)%, P <0.05]. There was no difference in C1 between hypertensive emergency group and stable hypertension group Statistical significance [(11.27 ± 3.77) ml / mmHg (1mmHg = 0.133kPa) × 10 vs (11.57 ± 3.88) ml / mmHg × 10, P 0.05), but the C2 of hypertensive emergency group was significantly lower than the stability (4.48 ± 2.14) ml / mmHg × 100 vs (5.41 ± 2.35) ml / mmHg × 100, P <0.05] .Conclusion: Compared with patients with stable hypertension, the patients with hypertension have lower FMD and arterioles Elastic index damage more serious.