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观察了急慢性应激时大鼠胃组织钙及cAMP含量的变化,以及异搏定抗应激性溃疡作用与胃组织钙及cAMP 含量变化之间的关系。结果表明:(1)应激后,在形成胃粘膜损害的同时,伴有胃粘膜钙含量明显增高,胃组织cAMP 含量则减少;(2)事先给予异搏定,胃组织cAMP 含量显著升高,同时胃粘膜损害明显减轻。提示应激时胃组织钙及cAMP 含量的变化在胃粘膜损害的形成中可能有一定的作用。
The changes of gastric tissue calcium and cAMP levels in rats with acute and chronic stress were observed, and the relationship between the effect of verapamil on stress ulcer and the changes of calcium and cAMP content in gastric tissue. The results showed that: (1) After stress, the formation of gastric mucosal lesions was accompanied by significantly increased calcium content in the gastric mucosa, and the cAMP content in the stomach tissue was decreased; (2) Prior to verapamil, cAMP content in gastric tissue was significantly increased. At the same time, gastric mucosal damage was significantly reduced. It is suggested that changes in the calcium and cAMP levels in gastric tissue during stress may play a role in the formation of gastric mucosal lesions.