论文部分内容阅读
本文报告了四川产的瓦松Cotyledon fimbriatus的药理研究。实验证明,该药具有心甙的特异性化学反应(Keller-killiani反应阳性),含钙量为0.05％(折合生药);可使在体蟾蜍心脏停止在收缩期;对离体蟾蜍心脏、离体兔心房和在体兔心都有强心作用。可使心脏标本的收缩振幅分别增加37.4％(n=10,P<0.001)、191％(n=8,P<0.001)和47％(n=8,P<0.001)。对在体兔心的作用性质与哇巴因相似,剂量适当(0.7g/kg iv)可使收缩振幅增加、频率减慢,中毒量(5.0-6.0g/kg iv)使心脏停止于舒张期。用相应的含钙溶液做的对照实验表明,此强心作用并非钙离子所致。
This article reports on the pharmacological research of Vaisson Cotyledon fimbriatus from Sichuan. Experiments have shown that the drug has a palpitation-specific chemical reaction (Keller-killiani reaction positive), calcium content of 0.05% (equivalent to crude drug); can stop the body in the systolic phase of the heart; on the heart of the body, from the body Both the rabbit heart and the rabbit heart have a strong heart. The contractile amplitude of cardiac specimens increased by 37.4% (n=10, P<0.001), 191% (n=8, P<0.001), and 47% (n=8, P<0.001), respectively. The effect on the in vivo rabbit heart is similar to that of ouabain. The proper dose (0.7g/kg iv) can increase the amplitude and frequency of contraction, and the amount of poisoning (5.0-6.0g/kg iv) stops the heart from diastole. . Control experiments with corresponding calcium-containing solutions showed that this potency is not due to calcium ions.