恶性脑胶质瘤(MG)由于其发病机理和生物学行为的复杂性,单凭提高手术技巧和改进现有的传统治疗措施,要想获得彻底治愈是不可能的,这已被一个世纪以来的神经外科实践所证实。随着对神经肿瘤分子机理认识的不断深化和基因工程技术的发展,近十年来MG基因治疗已由基础研究的探索,迅速过渡到了临床试验性治疗。 Malignant gliomas (MG) Due to the complexity of their pathogenesis and biological behavior, it is not possible to achieve complete cure solely by improving surgical skills and improving existing traditional treatments, which has been proven for over a century Neurosurgical practice confirmed. With the deepening understanding of the molecular mechanism of neural tumor and the development of genetic engineering technology, MG gene therapy has been rapidly transition from the basic research to clinical trial treatment in the past decade.