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为探讨食管癌血管内皮生长因子 (VEGF)及其受体 (Flt、KDR)、血管生成与食管癌临床病理特点的关系 ,采用免疫组织化学技术 ,检测了 5 0例人食管癌组织VEGF、Flt、KDR蛋白表达和微血管密度 (MVD)。分析VEGF、Flt、KDR和MVD及其与食管癌组织学分型、浸润深度、生长方式、淋巴结转移和预后的关系。结果显示 :VEGF及Flt、KDR阳性者MVD值显著高于阴性者 ,VEGF、Flt、KDR及MVD与食管癌浸润深度、淋巴结转移密切相关 ,并最终决定患者的预后。而与组织学分型、生长方式无关。因此认为 :VEGF、Flt、KDR与食管癌的血管生成密切相关 ,对其生长和浸润转移起促进作用 ,VEGF、Flt、KDR可以作为反映食管癌生物学行为的指标之一。
To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and its receptor (Flt, KDR) and the clinicopathological features of esophageal carcinoma in esophageal cancer, immunohistochemistry was used to detect the expression of VEGF, Flt , KDR protein expression and microvessel density (MVD). The relationship between VEGF, Flt, KDR, MVD and the histological type, depth of invasion, growth pattern, lymph node metastasis and prognosis of esophageal cancer were analyzed. The results showed that the MVD of VEGF, Flt and KDR were significantly higher than that of negative, VEGF, Flt, KDR and MVD were closely related to the depth of invasion and lymph node metastasis of esophageal carcinoma, and finally the prognosis of patients. And histological classification, growth has nothing to do. Therefore, VEGF, Flt and KDR are closely related to the angiogenesis of esophageal cancer and promote their growth and invasion and metastasis. VEGF, Flt and KDR may be used as one of the indicators to reflect the biological behavior of esophageal cancer.