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目的探讨连续胸椎旁神经阻滞联合全身麻醉用于乳腺癌手术对患者Ramsay评分及不良反应的影响。方法将192例行乳腺癌手术的患者随机分为研究组和对照组各96例。研究组乳腺癌手术中采用连续胸椎旁神经阻滞联合全身麻醉,对照组乳腺癌手术中采用全身麻醉,分别在不同时间点观察2组患者的Ramsay评分及不良反应。结果研究组在不同时间点Ramsay评分比较差异无统计学意义(P>0.05),且较对照组显著性偏低(P<0.05)。对照组24h时Ramsay评分显著性的高于4、8、12h时,差异有统计学意义(P<0.05);研究组各时点恶心、呕吐的不良反应发生率均低于对照组,差异有统计学意义(P<0.05)。结论连续胸椎旁神经阻滞联合全身麻醉用于乳腺癌手术,Ramsay评分相对较低且稳定,无过度镇静现象,且不良反应发生率低。
Objective To investigate the effect of continuous thoracic paravertebral nerve block combined with general anesthesia on Ramsay score and adverse reactions in breast cancer patients. Methods A total of 192 patients undergoing breast cancer surgery were randomly divided into study group (96 cases) and control group (96 cases). The study group underwent continuous thoracic paravertebral nerve block combined with general anesthesia in breast cancer surgery and general anesthesia in control breast cancer surgery. Ramsay scores and adverse reactions were observed in two groups at different time points. Results There was no significant difference in Ramsay score between study groups at different time points (P> 0.05), and was significantly lower than that in control group (P <0.05). In the control group, the Ramsay score at 24h was significantly higher than that at 4,8,12h (P <0.05). The incidence of nausea and vomiting in study group at each time point was lower than that in control group Statistical significance (P <0.05). Conclusions Continuous thoracic paravertebral nerve block combined with general anesthesia is used in breast cancer surgery. The Ramsay score is relatively low and stable with no excessive sedation and the incidence of adverse reactions is low.