论文部分内容阅读
目的探讨癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)、细胞角蛋白21-1片段(CYFRA21-1)等恶性肿瘤特异性标志物在肺癌患者早期诊断中的应用价值。方法 45例肺癌患者为A组,45例肺部良性病变患者为B组、45例体检健康人群为对照组,三组患者均实施静脉血样检查,对比三组患者上述指标检查结果的差异。结果 A组患者CEA、NSE、CA125、CYFRA21-1的水平[(28.5±11.6)μg/L、(44.3±18.5)μg/L、(86.6±24.2)U/ml、(23.6±10.6)μg/L]均明显高于B组[(2.4±0.5)μg/L、(13.5±3.0)μg/L、(29.2±11.5)U/ml、(2.8±1.8)μg/L]及对照组[(1.8±0.3)μg/L、(10.4±1.8)μg/L、(23.3±10.5)U/ml、(2.1±1.3)μg/L],差异具有统计学意义(P<0.05)。结论 CEA、NSE、CA125、CYFRA21-1等恶性肿瘤特异性标志物在肺癌患者早期诊断中具有明显的实用价值,医生可以联合测定以提升诊断准确性。
Objective To investigate the diagnostic value of specific markers such as CEA, NSE, CA125 and CYFRA21-1 in patients with lung cancer The value of early diagnosis. Methods Forty-five patients with lung cancer were Group A, 45 patients with benign lung disease were Group B, 45 healthy people were healthy, and all three groups were given venous blood samples. The differences of these indexes between the three groups were compared. Results The levels of CEA, NSE, CA125 and CYFRA21-1 in group A [(28.5 ± 11.6) μg / L, (44.3 ± 18.5) μg / L, (86.6 ± 24.2) L were significantly higher than those in group B [(2.4 ± 0.5) μg / L, (13.5 ± 3.0) μg / L, (29.2 ± 11.5) U / 1.8 ± 0.3μg / L, (10.4 ± 1.8) μg / L, (23.3 ± 10.5) U / ml and (2.1 ± 1.3) μg / L respectively). The difference was statistically significant (P <0.05). Conclusion CEA, NSE, CA125, CYFRA21-1 and other malignant tumor-specific markers in the early diagnosis of lung cancer patients have obvious practical value, the doctor can be combined to improve the diagnostic accuracy.