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目的探讨联合检测食管癌患者放疗前后血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)水平变化及其对患者生存预后的评估价值。方法选取125例食管癌患者(研究组)与45例健康对照者(对照组)。采用常规放疗方案对食管癌患者进行治疗,并采用酶联免疫吸附法(ELISA)检测食管癌患者放疗前后的CEA、CYFRA21-1水平,分析其与病情预后的相关性。结果研究组患者CEA、CYFRA21-1水平明显高于对照组(P<0.05)。经放疗后,食管癌患者的CEA、CYFRA21-1水平明显下降(P<0.05);CEA下降率为21.0%时,敏感度和特异度分别为87.3%和63.2%;CYFRA21-1下降率为43.0%时,敏感度和特异度均分别为82.3%和76.4%。血清CEA、CYFRA21-1水平下降组及未下降组间的生存率的差异均有统计学意义(P<0.05)。结论联合检测血清CEA和CYFRA21-1水平对食管癌患者的放疗疗效及生存预后的判定具有重要参考价值。
Objective To investigate the changes of serum carcinoembryonic antigen (CEA) and cytokeratin 19 (CYFRA21-1) level before and after radiotherapy in patients with esophageal cancer and evaluate their prognostic value. Methods 125 patients with esophageal cancer (study group) and 45 healthy controls (control group) were enrolled. The conventional radiotherapy was used to treat esophageal cancer patients. The levels of CEA and CYFRA21-1 in patients with esophageal cancer before and after radiotherapy were detected by enzyme-linked immunosorbent assay (ELISA), and their correlations with prognosis were analyzed. Results The levels of CEA and CYFRA21-1 in the study group were significantly higher than those in the control group (P <0.05). After radiotherapy, the levels of CEA and CYFRA21-1 in patients with esophageal cancer were significantly decreased (P <0.05). The sensitivity and specificity of CEA and CYFRA21-1 were 87.3% and 63.2% respectively when the rate of CEA decreased was 21.0% %, The sensitivity and specificity were 82.3% and 76.4% respectively. There were significant differences in the survival rates between the serum CEA and CYFRA21-1 levels in the declining group and the non-declining group (P <0.05). Conclusions The combined detection of serum CEA and CYFRA21-1 levels has an important reference value for the radiotherapy efficacy and prognosis of esophageal cancer patients.