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本文报道了用微核试验方法对维生素Ａ拮抗氯化汞（ＨｇＣｌ２）致小鼠胸骨骨髓多染红细胞微核作用的研究．结果表明，给小鼠补充维生素Ａ１．０２ｍｇ／ｋｇ及以上剂量时，有明显地拮抗ＨｇＣｌ２的致微核作用（Ｐ＜０．００１）．在ＨｇＣｌ２染毒前１２０ｍｉｎ和染毒后６０ｍｉｎ内给小鼠补充维生素Ａ１．０２ｍｇ／ｋｇ时，同样具有显著地降低其致微核作用（Ｐ＜０．０５～Ｐ＜０．００１）．一个月的试验结果表明，隔日给小鼠补充低剂量的维生素Ａ０．５ｌｍｇ／ｋｇ，也可产生显著地拮杭ＨｇＣｌ２１．０ｍｇ／ｋｇ的致微核作用．
This article reports the micronucleus test on vitamin A antagonism of mercury chloride (HgCl2) induced sarcoma marrow erythrocyte micronucleus in mice. The results showed that when mice were given vitamin A1.02mg / kg and above, they obviously antagonized the micronuclei induced by HgCl2 (P <0.001). Mice also had significant reductions in micronuclei (P <0.05 to P <0.001) when supplemented with A1.02 mg / kg 120 min before HgCl2 exposure and 60 min after exposure. A one-month trial showed that supplementation of mice with low doses of vitamin A 0.51 mg / kg every other day can also produce micronuclei that significantly antagonize HgCl 21.0 mg / kg.