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遗传因素在脑血管病(CVD)的发病中起重要作用,既可作为单独因素对CVD发病产生影响,亦可通过作用于某些危险因素(如高血压)发挥作用。血管紧张素转换酶(ACE)对血管紧张素Ⅱ的产生和缓激肽的降解有重要影响,两者是调节血管张力和平滑肌细胞增生的重要多肽。近年来的研究发现了ACE基因中内含子16的多态性缺失/插入现象。这段内含子与血液中ACE水平有关,多态性缺失的纯合子个体(DD基因型)呈现高水平的血清ACE。已
Genetic factors play an important role in the pathogenesis of cerebrovascular disease (CVD), which can affect the incidence of CVD as a separate factor and also act on certain risk factors such as hypertension. Angiotensin-converting enzyme (ACE) has a major impact on the production of angiotensin II and the degradation of bradykinin, both of which are important polypeptides that regulate vascular tone and smooth muscle cell proliferation. In recent years, the study found that intron 16 in the ACE gene polymorphism deletion / insertion phenomenon. This intron is associated with ACE levels in the blood, and individuals with a homozygous deletion (DD genotype) exhibit high levels of serum ACE. Already