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目的:检测探讨鼻腔鼻窦内翻性乳头状瘤CD44蛋白的表达及临床意义。方法:采用SP免疫组化染色方法,检测42例鼻腔鼻窦内翻性乳头状瘤及35例鼻腔鼻窦鳞状细胞癌CD44s、CD44V6及p53蛋白的表达。结果:(1)CD44s在鼻腔鼻窦内翻性乳头状瘤及鼻腔鼻窦鳞状细胞癌表达阳性率分别为85.7%(36/42)和37.1%(13/35),两组表达有非常显著性差异(P<0.01);(2)CD44V6在鼻腔鼻窦内翻性乳头状瘤及鼻腔鼻窦鳞状细胞癌表达阳性率分别为45.2%(19/42)和22.8%(8/35),两组表达有显著性差异(P<0.05);(3)p53在鼻腔鼻窦内翻性乳头状瘤及鼻腔鼻窦鳞状细胞癌表达阳性率分别为21.4%(9/42)和51.4%(18/35),亦具有非常显著性差异(P<0.01)。结论:CD44蛋白在鼻腔鼻窦内翻性乳头状瘤高度表达,在鼻腔鼻窦内翻性乳头状瘤恶变过程中可能起一定作用。
Objective: To investigate the expression of CD44 protein in nasal inverted papilloma and its clinical significance. Methods: The expression of CD44s, CD44V6 and p53 protein in 42 cases of nasal sinus inverted papilloma and 35 cases of nasal sinus squamous cell carcinoma were detected by SP immunohistochemical staining. Results: (1) The positive rates of CD44s in nasal sinus inverted papilloma and nasal sinus squamous cell carcinoma were 85.7% (36/42) and 37.1% (13/35), respectively (P <0.01). (2) The positive rates of CD44V6 in nasal sinus inverted papilloma and nasal sinus squamous cell carcinoma were 45.2% (19/42) and 22.8% (8/35), respectively (P <0.05). (3) The positive rates of p53 expression in inverted papilloma and nasal sinus squamous cell carcinoma were 21.4% (9/42) and 51.4% (18/35) ) Also had very significant difference (P <0.01). CONCLUSION: CD44 protein is highly expressed in inverted papilloma of nasal sinus and may play a role in the malignant transformation of inverted papilloma of nasal sinuses.