论文部分内容阅读
目的探讨乳腺淋巴瘤的临床病理学特征、诊断与鉴别诊断以及治疗与预后。方法收集5例乳腺淋巴瘤,免疫组化染色一抗选用CD20、CD79a、CD10、CD3、CD5、CD23、CD45RO、bcl-2、bcl-6、MYC、MUM-1、Ki-67和EBV,回顾性研究其临床病理资料及免疫组化并复习文献。结果 5例均为女性,平均年龄61.8岁,乳腺及同侧腋窝包块为最常见的症状。4例为原发性乳腺淋巴瘤(PBL),1例为继发性乳腺淋巴瘤(SBL)。Ann Arbor分期:I EA期3例,ⅡEA期1例,ⅣA期1例。经病理形态学观察及免疫组化染色,4例PBL均为弥漫性大B细胞性淋巴瘤(DLBCL),且均为非生发中心型,其中1例合并浸润性导管癌;1例SBL为慢性淋巴细胞性白血病/小淋巴细胞性淋巴瘤(CLL/SLL),合并浸润性导管癌。结论乳腺淋巴瘤罕见,乳腺淋巴瘤合并浸润性导管癌的碰撞瘤发生在乳腺部位更罕见,确诊及分型依赖组织病理学及免疫组化染色。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of breast lymphoma and its treatment and prognosis. Methods Five cases of breast lymphoma were collected. Immunohistochemical staining for CD20, CD79a, CD10, CD3, CD5, CD23, CD45RO, bcl-2, bcl-6, MYC, MUM-1, Ki-67 and EBV To study its clinical and pathological data and immunohistochemistry and review the literature. Results All 5 cases were female, with an average age of 61.8 years. The breast and ipsilateral axillary mass were the most common symptoms. 4 cases were primary breast lymphoma (PBL) and 1 case was secondary breast lymphoma (SBL). Ann Arbor staging: 3 cases of I EA, 1 case of ⅡEA and 1 case of ⅣA. Four cases of PBL were diffuse large B-cell lymphoma (DLBCL), all of which were non-germinal center type. One of them was associated with invasive ductal carcinoma. One case of SBL was chronic Lymphocytic leukemia / small lymphocytic lymphoma (CLL / SLL) with invasive ductal carcinoma. Conclusions Breast lymphoma is rare. Collision of invasive breast cancer with invasive ductal carcinoma occurs more rarely in the breast. Diagnosis and classification depend on histopathology and immunohistochemical staining.