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目的:通过观察仁术健胃颗粒对慢性萎缩性胃炎(CAG)脾气虚证大鼠内皮素(ET)和一氧化氮合酶(NOS)的影响,探讨仁术健胃颗粒预防和治疗慢性萎缩性胃炎的机制。方法:大鼠(除正常组)采用自由饮用MNNG溶液,灌胃40%的酒精,饥饱失常,疲劳运动相结合的方法复制CAG脾气虚证模型。然后将CAG脾气虚证模型大鼠随机分为相应各组。实验末检测各组大鼠血清中的ET和NOS水平。结果:CAG脾气虚证模型组大鼠ET和NOS水平与正常组比较都显著升高(P<0.05);仁术健胃颗粒12g/kg可显著降低CAG大鼠ET水平(P<0.05),6g/kg和3g/kg剂量组剂量组可显著降低CAG大鼠NOS的水平(P<0.05)。结论:仁术健胃颗粒治疗慢性萎缩性胃炎脾气虚证与降低机体ET和NOS水平有关。
Objective: To observe the effect of Renzhu Jianwei granule on endothelin (ET) and nitric oxide synthase (NOS) in rats with chronic atrophic gastritis (CAG) Gastritis mechanism. Methods: Rats (except the normal group) were given free MNNG solution, intragastric administration of 40% alcohol, impatient hunger and fatiguing, and combined with fatigue exercise to copy the model of CAG. Then the CAG spleen qi deficiency model rats were randomly divided into corresponding groups. At the end of experiment, serum ET and NOS levels in each group were detected. Results: The levels of ET and NOS in CAG group were significantly higher than those in normal group (P <0.05). Renji Jianwei Granule 12g / kg significantly reduced ET level in CAG rats (P <0.05) The dosage of 6g / kg and 3g / kg dose group could significantly reduce the level of NOS in CAG rats (P <0.05). Conclusion: Renzhu Jianwei Granule in treating chronic atrophic gastritis with deficiency of spleen - qi deficiency can reduce ET and NOS levels in the body.