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目的 :观察血液稀释加复方丹参注射液和生脉注射液对百草枯中毒大鼠的治疗效应。方法 :采用2 0 %百草枯以 2 5 mg/kg使大鼠中毒 ,中毒后 8～ 9小时分别进行常规激素 (C组 ,n=2 0 )、复方丹参注射液加山莨菪碱 (D组 ,n=2 0 )、血液稀释加复方丹参注射液和生脉注射液 (E组 ,n=2 0 )治疗。结果 :与实验中毒 (B组 ,n=2 0 )对比 ,存活率以 E组最高 (80 % ) ,肺系数及伊文思蓝含量也以 E组显著降低 (P<0 .0 5或 P<0 .0 1)。病理改变呈显著肺瘀血、肺水肿、肺组织炎症 ,大部分死亡鼠的肺实质呈肝样变性 ,而 E组病变改善最明显。结论 :控制性血液稀释加复方丹参注射液与生脉注射液对百草枯中毒大鼠治疗有显著效果
Objective : To observe the therapeutic effect of hemodilution plus compound salvia miltiorrhiza injection and Shengmai injection on paraquat poisoning rats. METHODS: Rats were poisoned with 20% paraquat at 25 mg/kg, and conventional hormones (group C, n=20), compound salvia miltiorrhiza injection and anisodamine (group D, 8 to 9 hours after poisoning). n=20), hemodilution plus compound salvia miltiorrhiza injection and Shengmai injection (group E, n=20). RESULTS: Compared with experimental poisoning (group B, n=20), the survival rate was highest in group E (80%), and the lung coefficient and Evans blue content were also significantly lower in group E (P<0.05 or P<0.05). 0 .0 1). Pathological changes were significant pulmonary, pulmonary edema, and lung tissue inflammation. The majority of dead rats showed hepatic degeneration of lung parenchyma, and the E group showed the most obvious improvement. Conclusion : Controlled hemodilution combined with Salvia miltiorrhiza injection and Shengmai injection have significant effects on the treatment of rats with paraquat poisoning