肝纤维化是慢性肝炎向肝硬化发展的必然途径，尽管肝活体组织检查术能明确诊断，但同样存在着对肝脏组织的损伤，可能引起某些并发症，不可能反复取材动态观察，同时由于肝脏病变的不均一，致取样上的误差。如何利用７０年代后期发展起来的血清学标志这种取材简便，利于动... Liver fibrosis is an inevitable way for the development of chronic hepatitis to cirrhosis. Although liver biopsy can confirm the diagnosis, there are also some damage to the liver tissue, which may cause some complications. It is impossible to obtain dynamic observation repeatedly. At the same time, Hepatic lesions are not homogeneous, resulting in sampling error. How to make use of the serological markers developed in the late 1970s?