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用放射免疫分析的方法测定23例慢性肾衰维持性血透（MDCRF）患者及22例慢性肾衰非透析（NpeRF）患者的血浆内皮素（Endothelin，ET）水平，并与正常人对照。结果，MDCRF组（190．1±31．9pg／ml）及NDCRF组（140.6±21．3pg／ml）ET含量均高于正常组（8．7±24．6pg／ml），且均有显著性差异（P＜005）；将MDCRF及NDCF进一步分为高血压与非高血压组时，MDCRF高血压组（13例）ET水平明显高于正常血压组（10例）（297.4±67．2比190．1±31．9pg／ml，P＜0，02），NDCRF高血压组（12例）ET水平明显高于正常血压级（10例）（241．0±52.8比140．6±21.3mm；ml，P＜0．05）．最后对上述结果进行了初步讨论．
The levels of endothelin (ET) in 23 patients with chronic renal failure with hemodialysis (MDCRF) and 22 with chronic renal failure without dialysis (NpeRF) were determined by radioimmunoassay and compared with normal controls. As a result, the levels of ET in the MDCRF group (190.1 ± 31.9 pg / ml) and NDCRF group (140.6 ± 21.3 pg / ml) were significantly higher than those in the normal group (8.7 ± 24.6 pg / ml) (P <0.05). The level of ET in MDCRF hypertension group (13 cases) was significantly higher than that in normotensive group (10 cases) (297.4 ± 67.2) when MDCRF and NDCF were further divided into hypertension group and non-hypertension group (190.1 ± 31.9pg / ml, P <0,02). The ET level in NDCRF group (12 cases) was significantly higher than that in normotensive group (10 cases) (241.0 ± 52.8 vs 140.6 ± 21.3 mm; ml, P <0.05). Finally, the above results were initially discussed.