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目的 观察原发性肾病综合征 (PNS)患者是否存在胰岛素抵抗 (IR)及其意义。方法 收集临床已经确诊的4 6例PNS患者和 2 0例正常对照组 (NC)的一般临床资料 ,并检测所有实验对象的空腹血糖 (FBG)、胰岛素(FISN)、C -肽 (FCP)、血脂及肾功能 ,计算胰岛素敏感指数 (ISI) ,并进行对照分析。结果 PNS组与NC组间年龄、性别比例、体质量指数 (BMI)差异均无显著性 ,但原发性肾病综合征患者的舒张压 (DBP)、FBG、FISN、FCP、总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白 (LDL -C)、高密度脂蛋白 (HDL -C)、血尿酸 (UA)均显著高于正常对照组 (P <0 .0 1或P <0 .0 5 ) ,ISI显著低于正常对照组 (P <0 .0 1)。结论 PNS患者存在IR ,其原因可能与患者血压升高、血脂和尿酸代谢紊乱有关。
Objective To observe whether insulin resistance (IR) exists in patients with primary nephrotic syndrome (PNS) and its significance. Methods The clinical data of 46 clinically confirmed patients with PNS and 20 normal controls (NC) were collected and the levels of fasting blood glucose (FBG), insulin (FISN), C - peptide (FCP) Blood lipids and renal function, insulin sensitivity index (ISI) were calculated and compared. Results There were no significant differences in age, sex ratio and body mass index (BMI) between PNS group and NC group. However, diastolic blood pressure (DBP), FBG, FISN, FCP and total cholesterol (TC) , Triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and serum uric acid were significantly higher than those in normal control group (P <0.01 or P < 0. 05), ISI was significantly lower than the normal control group (P <0. Conclusion There is IR in patients with PNS, the reason may be related to elevated blood pressure, dyslipidemia and uric acid metabolism.