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目的:探讨老年(年龄≥60岁)舌体鳞状细胞癌患者的临床特点、治疗方法和预后以及影响预后的主要因素。方法:选择1990-01-2002-12中山大学附属肿瘤医院首治的经病理确诊的老年舌体鳞癌患者共153例。应用Kaplan-Meier法分析生存结果,通过Cox回归模型确立影响预后的独立因素。结果:153例老年舌体鳞癌患者的中位生存时间为55个月;2年生存率为59.8%,5年生存率为49.3%。单因素分析显示,影响老年舌体鳞癌患者预后的因素包括淋巴结有无转移、分期、手术治疗及复发等,P<0.05。多因素分析显示,影响预后的独立因素为复发,P<0.05。结论:老年舌体鳞癌患者早期以单一手术治疗为宜,晚期患者以手术为主的综合治疗预后较好。老年舌体鳞癌患者并存病较多,但不影响预后,亦不影响治疗方式的选择。
Objective: To investigate the clinical features, treatment and prognosis of elderly patients (≥60 years old) with tongue squamous cell carcinoma and the main factors influencing the prognosis. Methods: A total of 153 elderly patients with squamous cell carcinoma of the tongue diagnosed by pathology were selected as the first affiliated hospital affiliated to Sun Yat-sen University Cancer Hospital from January 1990 to December 2002. Survival results were analyzed using Kaplan-Meier method and independent factors influencing prognosis were established by Cox regression model. Results: The median survival time of 153 elderly patients with tongue squamous cell carcinoma was 55 months. The 2-year survival rate was 59.8% and the 5-year survival rate was 49.3%. Univariate analysis showed that the prognosis of elderly patients with tongue squamous cell carcinoma include lymph node metastasis, staging, surgical treatment and recurrence, P <0.05. Multivariate analysis showed that the independent factor influencing prognosis was recurrence (P <0.05). Conclusion: The elderly patients with squamous cell carcinoma of tongue tend to be treated by single operation in the early stage, while the comprehensive treatment with advanced operation in advanced stage is better prognosis. Elderly tongue squamous cell carcinoma patients with coexisting disease more, but does not affect the prognosis, does not affect the choice of treatment.