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目的:考察蒸制温度、蒸制时间对补益类药生成5-羟甲基糠醛(5-HMF)的影响。方法:利用顶空气相色谱-质谱法(HS-GC-MS)检测其生成的5-HMF。结果:不同类补益药蒸制都会生成5-HMF,蒸制温度、蒸制时间在补益类药生成5-HMF过程中均有重要影响。蒸制温度不超过80℃,补益类药蒸制几乎不生成5-HMF,蒸制时间对5-HMF生成亦没有明显影响;但蒸制温度超过80℃,蒸制温度及蒸制时间对5-HMF生成的影响则明显不同。80℃﹤蒸制温度﹤130℃时,补益类药蒸制产生5-HMF的量呈平稳较快增长。当蒸制温度>140℃时,补益类药蒸制生成5-HMF的量呈显著变化,蒸制温度为140℃时,5-HMF生成量较100℃时增加多达10余倍。在蒸制温度超过180℃时,补益类药蒸制随温度的升高5-HMF生成量则逐渐降低,且蒸制时间越长,5-HMF的生成量相应越少。结论:补益类中药材蒸制过程中需严格控制温度和时间。
Objective: To investigate the effects of steaming temperature and steaming time on the 5-HMF production of tonic drugs. Methods: The 5-HMF was detected by headspace-gas chromatography-mass spectrometry (HS-GC-MS). Results: 5-HMF was produced by steaming of different types of tonic agents. The steaming temperature and steaming time all had important influence on the 5-HMF production by replenishing drugs. The steaming temperature does not exceed 80 ℃, steaming of tonic medicines almost does not produce 5-HMF, steaming time has no obvious effect on the generation of 5-HMF; but the steaming temperature exceeds 80 ℃, steaming temperature and steaming time of 5 The impact of -HMF generation is significantly different. When 80 ℃ 140 ℃, the amount of 5-HMF produced by steaming of tonic agents changed significantly. When steaming temperature was 140 ℃, the amount of 5-HMF increased by more than 10 times as compared with 100 ℃. When the steaming temperature is over 180 ℃, the yield of 5-HMF decreases with the increase of temperature, and the longer the steaming time, the less the amount of 5-HMF is produced. CONCLUSION: Tonic medicine should be controlled strictly in temperature and time.