早在本世纪初,已有人提出了抗体具有识别正常细胞和恶性细胞的能力,井设想有可能以此作为定向的“导弹”式治疗剂。直到五十年代,Pressman和Bale等才在动物体内Wagner骨肿瘤和Walker癌上首次证实了抗体的专一性定位。七十年代中,由于人们对某些分泌性人体肿瘤标记物的 As early as the beginning of this century, it has been proposed that antibodies have the ability to recognize normal cells and malignant cells, and it is envisaged that this could be used as a directed “missile” therapeutic agent. It was not until the 1950s that Pressman and Bale first demonstrated the specific localization of antibodies on Wagner bone tumors and Walker cancers in animals. In the 1970s, due to people’s identification of certain secreted human tumor markers