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目的:观察麻杏甘石汤序贯给药治疗外感发热的临床疗效及其量效关系的研究。方法:180例外寒内热型外感发热患者随机分为3组,每组60例。观察组采用麻杏甘石汤序贯给药,常规组采用麻杏甘汤常规给药,对照组采用头孢氨苄异形片给药。观察5 d。以体温起效、复常时间,平均治疗时间,治疗前后主要症状和体征积分变化,体温各时段均值与服药间隔的关系,体温复常所用的中药数量及平均用药时间进行比较。结果:观察组退热起效时间、复常时间、治疗后症状积分明显减少,体温显愈率、临床疗效总有效率明显高于常规组,差异有显著性统计学意义(P<0.01)。结论:在所用中药总数量无差异情况下,麻杏甘石汤序贯给药与常规给药相比,具有起效快、体温复常时间短、退热作用稳定、不易反复等优势,能明显缩短病程、改善发热及临床症状,减轻病人痛苦。
Objective: To observe the clinical efficacy and the dose-effect relationship of “Maxing Ganshi Decoction” sequential administration in treating exogenous fever. Methods: One hundred and eighty exogenous febrile exogenous fever patients were randomly divided into three groups (60 in each group). The observation group was administered with Maxing Ganshi Decoction. The conventional group was given Maxinggan Decoction, while the control group was given cephalexin. Observed for 5 days. The onset of body temperature, the recovery time, the average treatment time, changes of main symptoms and signs before and after treatment, the mean value of body temperature and the interval of medication, the number of traditional Chinese medicines used for body temperature recovery and the average medication time were compared. Results: The onset time of onset of fever, the time of recovery, and the decrease of symptom score after treatment in the observation group were significantly higher than those in the conventional group (P <0.01). CONCLUSION: Compared with the conventional administration, the Maxinggan soup has the advantages of rapid onset of action, short recovery time of body temperature, stable and effective antipyretic effect, which can be significantly shortened when there is no difference in the total amount of traditional Chinese medicine used Course of disease, improve fever and clinical symptoms, reduce patient pain.