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胰岛素样生长因子系统(insulin-like growth factor system,IGF system)在细胞增殖、转化和抑制凋亡中起重要作用,与肿瘤的发生、发展关系密切已成为国内外研究热点。本文对IGF系统的组成、结构、功能及其在妇科肿瘤的研究进展进行综述,最后对IGF系统在妇科肿瘤的应用前景作出展望。
Insulin-like growth factor system (IGF-1) plays an important role in cell proliferation, transformation and apoptosis inhibition. It has become a hot research topic both at home and abroad due to its close relationship with tumorigenesis and development. This review summarizes the composition, structure and function of IGF system and its progress in gynecologic oncology. Finally, the future of IGF system in gynecologic oncology is prospected.