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为寻找疗效满意、不良反应小的中药复方治疗肺间质纤维化 ,将 48只 SD大鼠 ,分为正常对照组、模型组、补气通肺饮组、激素组各 12只。补气通肺饮组口服补气通肺饮 ,激素组口服泼尼松 ,疗程均为 2 8d。分别于第 7d和 2 8d处死动物 ,作肺组织形态学观察、肺组织羟脯氨酸测定、血浆 TXA2 / PGI2测定。补气通肺饮治疗后肺泡炎及肺纤维化明显减轻 ,TXA2 / PGI2 低于模型组及激素组。提示补气通肺饮治疗肺间质纤维化疗效满意。
In order to find satisfactory Chinese herbal complexes with less adverse reactions and treat pulmonary interstitial fibrosis, 48 SD rats were divided into normal control group, model group, Buqi Tongfei Yin group and hormone group. Buqi Tongfeiyin group was treated with Buqi Tongfei Yin and hormone group was treated with prednisone. The course of treatment was 28 days. Animals were sacrificed on day 7 and day 28, respectively, for histological observation of lung tissue, determination of hydroxyproline in lung tissue, and determination of plasma TXA2/PGI2. After treatment of Buqi Tongfeiyin, alveolitis and pulmonary fibrosis were significantly reduced, and TXA2/PGI2 was lower than that of model group and hormone group. Tips Buqi Tongfeiyin treatment of pulmonary interstitial fibrosis was satisfactory.