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目的观察胸腔热灌洗联合榄香烯乳治疗恶性胸腔积液的疗效,探讨治疗恶性胸腔积液的有效方法。方法59例恶性胸腔积液病人随机分成2组,治疗组30例采用胸腔内置管热灌洗联合榄香烯乳治疗;对照组29例采用顺铂(DDP)100mg/m2胸腔内注入。对2组病人的治疗效果进行评估。结果治疗组30例中显效23例,有效6例,无效1例,总有效率96.7%;对照组29例中显效9例,有效8例,无效12例,总有效率58.6%。2组总有效率比较差异有统计学意义(P<0.05)。治疗组1年生存数与死亡数分别为18例、12例,对照组分别为9例、20例。2组1年生存率分别为60.0%、31.0%,差异有统计学意义(P<0.05)。2组均无严重不良反应。结论胸腔内热灌洗联合榄香烯乳治疗恶性胸腔积液有效率高,毒副作用小,病人易于耐受。
Objective To observe the curative effect of thoracic thermal lavage combined with elemene in the treatment of malignant pleural effusion and to explore an effective method for the treatment of malignant pleural effusion. Methods Fifty-nine patients with malignant pleural effusion were randomly divided into two groups. Thirty patients in the treatment group were treated with intra-thoracic thermal catheter combined with elemene. The control group received intrapleural injection of cisplatin (DDP) 100 mg / m2. The treatment effect of two groups of patients was evaluated. Results In the treatment group, 23 cases were markedly effective in 23 cases, 6 cases were effective, 1 case was ineffective and the total effective rate was 96.7%. In the control group, 9 cases were markedly effective, 8 cases were effective and 12 cases were ineffective. The total effective rate was 58.6%. The total effective rate in the two groups was significantly different (P <0.05). The number of one-year survival and death in the treatment group were 18 cases, 12 cases, the control group were 9 cases, 20 cases. The 1-year survival rates of the two groups were 60.0% and 31.0%, respectively, with significant differences (P <0.05). No serious adverse reactions were found in both groups. Conclusion Intrathoracic heat lavage combined with elemene is effective in treating malignant pleural effusion with small toxic and side effects and is easily tolerated in patients.